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Psilocybin Plant Medicine | Moyenda Institute

Plant Medicines are often referred to as herbal remedies and have been an integral part of human healing traditions for centuries with some stifled remedies making a comeback.

In this series, we explore the research on the effects and neurological impacts of the Plant Medicine: Psilocybin.

Psilocybin is a natural compound found in certain mushrooms, especially those of the Psilocybe genus, and it holds the potential to unlock profound insights within one's psyche.

Peer-reviewed studies highlight psilocybin's neurological impact, involving its interaction with serotonin receptors in the brain.

This interaction triggers changes in perception, fostering heightened introspection.


Psilocybin engages specific receptors, influencing perception and permitting deeper self-reflection. (See Footnote: Griffiths et al., 2016)

Research suggests psilocybin's therapeutic potential in addressing anxiety, depression, and PTSD as it provides relief for many mental health treatments. (See Footnote: Carhart-Harris et al., 2016)

Psilocybin also exhibits potential in significantly reducing depression symptoms as a comprehensive study revealed substantial decreases in depression among patients with life-threatening cancer who were offered psilocybin treatments. (See Footnote: Johnson et al., 2008)


Another study explored how effective and beneficial psilocybin treatments with psychological support were to patients resistant to conventional depression treatments. (See Footnote: Muttoni et al., 2019)

It is also proven that psilocybin can contribute to an enhanced emotional well-being with increased empathy and positive effects in those who partake in psilocybin treatments. (See Footnote: Gasser et al., 2015)

Scientific studies affirm that psilocybin promotes neuroplasticity; which contributes to our overall mental well-being and offers relief from the burdens of psychological distress. (See Footnote: Johnson et al., 2017)

This increased neuroplasticity forms new neural connections for the brain to adapt and restructure itself, potentially contributing to the resolution of mental health challenges. (See Footnote: Mason et al., 2020)

Studies illuminate how psilocybin induces altered states of consciousness that can become conduits for psychological healing for deep-seated issues and foster mental clarity. (See Footnote: Lebedev et al., 2015)

Scientific investigations propose that psilocybin induces alterations in our Default Mode Network (DMN), a brain network associated with self-referential thoughts, introspection and the sense of ego.

Psilocybin's impact on the DMN may lead to a temporary dissolution of the boundaries of the ego by fostering an expanded sense of Self and interconnectedness. (See Footnote: Tagliazucchi et al., 2014)


In basic terms, psilocybin has been associated with increased brain flexibility, allowing it to adapt and potentially alleviate mental health challenges.

These findings emphasize the transformative potential that psilocybin has in reshaping the way our brains function, affecting the way we think by providing new perspectives and insights.

In addition, the spiritual experiences with psilocybin holds profound significance as it is recognized for making a transformative impact on our sense of purpose and perceptions on unity. (See Footnote: Watts et al.,2017)

Overall, psilocybin can have a profound healing effect that affects our body, mind, and spirit. In essence, psilocybin emerges as a natural holistic healer.


As we delve into the enchantment of psilocybin, supported by scientific insights, it becomes clear that its role in plant medicine journeys is not just mystical—it's grounded in evidence.

Beyond fascination lies a realm of healing, where body, mind, and spirit converge on a transformative journey of exploration and discovery.

Always approach the exploration of psilocybin and plant medicine journeys with a spirit of respect, mindfulness, and consider seeking guidance from experienced practitioners.

Consulting with an experienced integration professional is strongly encouraged before embarking on the transformative journey psilocybin may offer.

Those new to Plant Medicines should consult with Moyenda Institute for valuable insights and expert guidance on safe and effective practices.

Contact Moyenda Institute for a free Consultation.


Griffiths, R. R., et al. (2016). Neuroplasticity and the Default Mode Network.

Carhart-Harris, R. L., et al. (2016). Therapeutic Potential of Psilocybin in Mental Health Treatment.

Johnson, M. W., et al. (2008). Psilocybin Treatment for Depression in Patients with Life-Threatening Cancer.

Muttoni, S., et al. (2019). Psilocybin as an Alternative Approach for Treatment-Resistant Depression.

Gasser, P., et al. (2015). Emotional Well-Being Enhancement through Psilocybin.

Johnson, W. et al. (2017). The Role of Psilocybin in Alleviating Symptoms of Anxiety and Depression.

Lebedev, A. et al. (2015). Altered States of Consciousness Induced.

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